Friday, November 30, 2012

Sandy and the Age of Superstorms (Little green footballs)

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U.S. top court to consider whether to review gay marriage cases

(Reuters) - The nine justices of the U.S. Supreme Court are widely expected to decide in a private meeting on Friday to enter the legal fray raging over same-sex marriage.

An announcement to take a case could come as early as Friday afternoon or Monday morning.

Thirty-one of the 50 states have passed constitutional amendments banning gay marriage while Washington, D.C., and nine other states have legalized it, three of them on Election Day, November 6.

At issue is the 1996 Defense of Marriage Act, or DOMA, passed by Congress, which only recognizes marriages between a man and a woman. Gay men and lesbians have specifically challenged a part of the law that prevents them from receiving federal benefits that heterosexual couples receive.

The high court is considering requests to review five cases that challenge the law as a violation of the equal protection provisions of the U.S. Constitution.

Most courts to address the issue, including federal appeals courts in Boston and New York, have found the law's contested provision unconstitutional.

The Supreme Court is expected to take at least one of the challenges, as the court typically reviews lower-court decisions that invalidate a federal law.

Even in states where same-sex marriage is legal, the couples do not qualify for a host of federal benefits because of DOMA.

If the court accepts one of the cases, the oral arguments will likely take place in early 2013, with a ruling expected by the end of the court term in June.

If the court invalidates the law, states could still be free to legalize or deny same-sex marriages on their own terms.

Friday's scheduled court conference is one of the Supreme Court's regular weekly sessions at which it considers what new cases to add to the calendar.

The meetings, attended only by the justices, are held in a small conference room adjacent to the chambers of Chief Justice John Roberts.

The justices vote in order of seniority, and while it takes five of the nine for a majority decision in a dispute, it takes only four votes to add a case to the agenda and schedule oral arguments.

CALIFORNIA'S BAN

The court is also considering whether to review a challenge to California's ban on same-sex marriage, known as Proposition 8, which voters narrowly approved in 2008. The California case, Hollingsworth v. Perry, had sought to establish a constitutional right to marry for gays and lesbians.

The 9th Circuit in February found the gay marriage ban unconstitutional, but it ruled narrowly in a way that only affected California and not the rest of the country, finding that the state could not take away the right to same-sex marriage after previously allowing it. No other state to legalize gay marriage has later banned it.

If the Supreme Court later takes the case, it could follow the 9th Circuit's decision and also rule narrowly, requiring same-sex marriage only in California but not the rest of the country. Or it could recognize a right to marriage equality.

If the justices decline to take the case, the 9th Circuit's opinion would stand, and same-sex marriage would resume in California. That would significantly boost the number of same-sex couples able to marry, given the state's large size.

The Supreme Court is also considering an appeal from the state of Arizona, asking the court to revive a state version of DOMA. The Arizona law, which the 9th Circuit invalidated, eliminated domestic partner healthcare benefits for gay and lesbian state employees. Same-sex couples in Arizona cannot marry, under that state's constitutional ban passed in 2008.

(Reporting by Terry Baynes in New York; Editing by Howard Goller and Cynthia Osterman)

Source: http://news.yahoo.com/u-top-court-consider-whether-review-gay-marriage-060517051.html

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Tony Lindsey, Cousin of Honey Boo Boo, Arrested for Gorilla Suit Antics

Source: http://www.thehollywoodgossip.com/2012/11/tony-lindsey-cousin-of-honey-boo-boo-arrested-for-gorilla-suit-a/

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Thursday, November 29, 2012

GE's service push could bring profit margin boost

(Reuters) - General Electric Co plans to unveil on Thursday a new push into service businesses, with a series of programs to help airlines, railroads and hospitals that use its heavy equipment operate more efficiently.

The drive is part of the largest U.S. conglomerate's effort to boost its margins and make more money in a sluggish economy, as sales of services are more profitable equipment than sales of jet engines, locomotives and other equipment.

GE's pitch is that by tweaking how they operate, its customers can cut their own costs. For example, a 1 percent cut in the amount of fuel the global aviation industry uses could generate $30 billion in total savings, GE estimates.

Investors said the company's service business has been more stable in uneven economic times than equipment sales. Last year GE's service business, including maintenance to its products, generated $42 billion in revenue, approached half GE's industrial sales.

"Given the environment, some of the uncertainties, etc., services is an area that plays for the long term because of the...ongoing desire from customers for new levels of productivity," said Steve Bolze, the chief executive officer of GE's power and water business, who is also heading up the company's services push.

The company is developing software systems that analyze data on how its turbines and other equipment are used to find ways to run them more efficiently and at lower cost, Bolze said. It plans to discuss them at an event in San Francisco on Thursday.

GE said it has lined up customers for its new services including: U.S. railroad Norfolk Southern Corp , low-cost carrier AirAsia Bhd and drug and medical device maker Abbott Laboratories

MARGIN PUSH

The drive is part of Chief Executive Jeff Immelt's push to raise GE's profit margins by 0.5 percent to 0.7 percent of sales next year, a rise investors expect would propel the company's industrial operating profit to about 16 percent of sales, up from 14.9 percent in 2011.

"Growing margins into the future is a big credibility point for the leadership team and one we take seriously," Immelt told investors at a September meeting held at the company's training campus in Crotonville, New York.

GE also said at the meeting that it expects services revenue to grow by 5 percent to 10 percent a year over the next few years, reaching $50 billion to $60 billion by 2015, with the service backlog forecast to rise to $175 billion from $153 billion at the end of the third quarter.

During the 2007-2009 recession, service contracts played an important stabilizing role in sales at GE and peers including United Technologies Corp , analysts noted.

"Increasing exposure to strong incremental margin businesses like services can help the company reach its margin targets in an environment where you may not get the same kind of manufacturing productivity leverage that you have in a higher-growth environment," said Daniel Holland, an analyst at Morningstar in Chicago who covers GE.

Fairfield, Connecticut-based GE has been ramping up its software focus since last year, when it hired former Cisco Systems Inc executive Bill Ruh to build a data-analytics center in San Ramon, California.

(Reporting by Scott Malone in Boston; Editing by Leslie Gevirtz)

Source: http://news.yahoo.com/ges-push-could-bring-profit-margin-boost-121518972--sector.html

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Details of Halo makers' upcoming game "Destiny" leaked online ...

Bungie?s next project may have inadvertently been leaked to the world ahead of schedule. According to supposedly documents sent to video game news sites IGN and Kotaku, the next game by the makers of the popular FPS series ?Halo? will be called ?Destiny?.?

?

Bungie confirmed that the game is indeed called just that, and is set sometime in the future where humanity has colonized the stars and is now experiencing an attack by alien forces. Forced into their last city and protected by a massive alien ship known as ?The Traveler?, players will take the role of a ?knight? who is tasked with defending the remnants of humanity whilst exploring space, finding the source of the alien menace, and eventually overcoming it.

?

The game is touted to be an ambitious project by Bungie, and will feature an MMO style of gameplay that will span the universe and compel players to interact in a very sociable manner. It?s an experience that?s being compared to the Star Wars franchise, and according to Bungie co-founder Jason Jones is ?designed for your inner seven year old. We want to make it feel like a mythic adventure?.

?

Following the leak that showed various information and artwork from the game, Bungie has confirmed some of the stuff are real, and countered things by posting a story and image on their own website, with a simple message relayed to readers and addressing the leak:

?

?Go ahead. Take a peek. It?s alright. We weren?t quite ready, but we will be soon, and we can?t wait to finally show you what we?ve really been up to.

?

Stick around, we haven?t even started yet.?

?

Some of the artwork has been debunked by Kotaku and traced to sites like DeviantArt. The document has revealed a Destiny logo as well, which includes the PS3 and Xbox 360 icons, as well as a URL address that is currently password protected.

?

According to IGN, word first emerged about ?Destiny? on May when court documents revealed its name, as well as four planned installments and DLC content. A release date hasn?t been confirmed yet, but details may arise sooner than later. ? TJD, GMA News

Source: http://www.gmanetwork.com/news/story/284198/scitech/gaming/details-of-halo-makers-upcoming-game-destiny-leaked-online

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Study focuses on returning wounded soldiers to meaningful civilian lives

Study focuses on returning wounded soldiers to meaningful civilian lives [ Back to EurekAlert! ] Public release date: 29-Nov-2012
[ | E-mail | Share Share ]

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research

DETROIT Record numbers of soldiers are returning from Iraq and Afghanistan with serious spinal cord injuries (SCI). Medical advancements can help heal their physical wounds, but little is known about how these veterans re-engage with their communities and rebuild meaningful lives. "How do they transition back to family and community life? How do they adjust to their physical impairments? And how do they reconfigure their homes, their work and their lives?" asked Cathy Lysack, professor of occupational therapy and gerontology at Wayne State University. Drs. Lysack and Mark Luborsky, professor of anthropology and gerontology at Wayne State University, are co-principal investigators on a new $456,000 grant from the Department of Defense to explore those questions.

The three-year grant, shared between WSU's Institute of Gerontology and the University of Maryland, Baltimore County, will study how service members and veterans with SCI reintegrate into society. Luborsky believes "the time is ripe to discover how military personnel with SCI create a sense of connection."

"After the medical issues are stabilized, the key to long-term success for patients is how they establish their cultural identities and create meaningful connections to communities," he said. "This project will move the science and research forward toward interventions to help all people with SCI maintain their independence and ability to function in community life."

A total of 60 spinal cord injured veterans will be recruited at three levels of recovery: less than 12 months, 12 to 24 months, and 2 to 5 years after discharge from inpatient rehabilitation. The research teams will interview service members in depth about their long-term goals, values and expectations for meaningful community reintegration and social participation.

"Traumatic spinal cord injury is severe and permanent, but it need not be a catastrophic disability," said Lysack. While researchers have learned a lot about how civilians with SCI reintegrate into family and community life, veterans and service members may approach it much differently.

"These are soldiers uber males and females whose role in the military has been to fight and protect," she said. "We need to learn how they make a successful transition to civilian life." The goal of this study is to support the development of innovative strategies and systems that will improve the long-term outlook for service members with traumatic injuries and their families. "This is not about managing a disability," Lysack said. "It's about rebuilding a life."

###

PR Contact: Cheryl Deep - cheryldeep@wayne.edu

The Institute of Gerontology researches the aging process, educates students in gerontology, and presents programs on aging issues relevant to professionals, caregivers and older adults in the community (www.iog.wayne.edu). The Institute is part of the Division of Research at Wayne State University, one of the nation's preeminent public research institutions in an urban setting. For more information about research at Wayne State University, visit http://www.research.wayne.edu.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Study focuses on returning wounded soldiers to meaningful civilian lives [ Back to EurekAlert! ] Public release date: 29-Nov-2012
[ | E-mail | Share Share ]

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research

DETROIT Record numbers of soldiers are returning from Iraq and Afghanistan with serious spinal cord injuries (SCI). Medical advancements can help heal their physical wounds, but little is known about how these veterans re-engage with their communities and rebuild meaningful lives. "How do they transition back to family and community life? How do they adjust to their physical impairments? And how do they reconfigure their homes, their work and their lives?" asked Cathy Lysack, professor of occupational therapy and gerontology at Wayne State University. Drs. Lysack and Mark Luborsky, professor of anthropology and gerontology at Wayne State University, are co-principal investigators on a new $456,000 grant from the Department of Defense to explore those questions.

The three-year grant, shared between WSU's Institute of Gerontology and the University of Maryland, Baltimore County, will study how service members and veterans with SCI reintegrate into society. Luborsky believes "the time is ripe to discover how military personnel with SCI create a sense of connection."

"After the medical issues are stabilized, the key to long-term success for patients is how they establish their cultural identities and create meaningful connections to communities," he said. "This project will move the science and research forward toward interventions to help all people with SCI maintain their independence and ability to function in community life."

A total of 60 spinal cord injured veterans will be recruited at three levels of recovery: less than 12 months, 12 to 24 months, and 2 to 5 years after discharge from inpatient rehabilitation. The research teams will interview service members in depth about their long-term goals, values and expectations for meaningful community reintegration and social participation.

"Traumatic spinal cord injury is severe and permanent, but it need not be a catastrophic disability," said Lysack. While researchers have learned a lot about how civilians with SCI reintegrate into family and community life, veterans and service members may approach it much differently.

"These are soldiers uber males and females whose role in the military has been to fight and protect," she said. "We need to learn how they make a successful transition to civilian life." The goal of this study is to support the development of innovative strategies and systems that will improve the long-term outlook for service members with traumatic injuries and their families. "This is not about managing a disability," Lysack said. "It's about rebuilding a life."

###

PR Contact: Cheryl Deep - cheryldeep@wayne.edu

The Institute of Gerontology researches the aging process, educates students in gerontology, and presents programs on aging issues relevant to professionals, caregivers and older adults in the community (www.iog.wayne.edu). The Institute is part of the Division of Research at Wayne State University, one of the nation's preeminent public research institutions in an urban setting. For more information about research at Wayne State University, visit http://www.research.wayne.edu.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-11/wsu--sfo112912.php

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Mid Day Buzzers: Green Mountain Coffee, Apple Inc, Yingli Green Energy, PVH Corp

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Wednesday, November 28, 2012

Ratan Tata positive, says India's outlook not as bad

Last updated on: November 28, 2012?17:43 IST

Tata Group head Ratan Tata has said that though India had many changes of government, the outlook 'might not be as bad' as one might think.

However, Tata, who was awarded an honorary Doctorate of Business from the University of New South Wales, said he feels that the fabric of Indian values and ethics was 'slowly deteriorating', especially in the business community.

He made it clear that his group, India's largest conglomerate, was based on strong ethics and would not participate in corruption and bribery.

Click NEXT to read further. . .


Image: Ratan Tata addressing a gathering.
Photographs: Umar Ganie/Rediff.com

Last updated on: November 28, 2012?17:43 IST

"India (may have) had many changes of government, but the outlook 'might not be as bad as you might think . . . I would have hope'," The Australian quoted him as saying.

Tata said he expects China to move towards democracy.

He said many democracies would also have to find ways of 'enforcing what they want to do if they want to move forward'.

Tata said that Australia and India should step up bilateral trade ties, especially in high-technology areas, adding that there were good reasons for the countries to "do much more together than they have done".

Click NEXT to read further. . .


Image: Ratan Tata.
Photographs: Reuters

Last updated on: November 28, 2012?17:43 IST

"Australia is a vibrant economy," Tata said. There were areas of high technology where Australia was 'at the forefront' and India could benefit from this.

"India seeks some of the technology that Australia produces," the 74-year-old chairman of Tata Group said.

At the same time, he said India had a much larger population of some 350 million middle class consumers, which would grow as high as 600 million.

Trade between Australia and India has soared over the past decade, growing from $3.1 billion in 2000 to more than $21 billion in 2011.

Click NEXT to read further. . .


Image: Ratan Tata.
Photographs: Reuters

Last updated on: November 28, 2012?17:43 IST

Demand for Australian commodities such as coal, wool and copper is driving the trade, but education is also a large and growing aspect of the relationship.

"It would be terrific to see Australian companies have products which could have access to a market of that scale," Tata said.

He said there needed to be more interchange between the people of Australia and India, including student exchanges and internships.

"There needs to be a greater bonding of people, which will come from such moves," he said.

Tata said he would like to see his company do more business with Australia. At the moment, its main business in Australia is buying iron ore and coking coal.

Click NEXT to read further. . .


Image: Ratan Tata.
Photographs: Danish Siddiqui/Reuters

Last updated on: November 28, 2012?17:43 IST

Tata said India was 'slowly deteriorating in the fabric of its values and ethics, especially in the business community'.

But he said the Tata Group was based on strong ethics and would not participate in corruption and bribery. Tata said India had had many changes of government, but the outlook 'might not be as bad as you might think'.

"I would have hope," he said. Tata expects China to move towards democracy. He said many democracies would also have to find ways of 'enforcing what they want to do if they want to move forward'.

Click NEXT to read further. . .


Image: Ratan Tata.
Photographs: Reuters

Last updated on: November 28, 2012?17:43 IST

Tata Group is India's largest corporation with an annual turnover of more than $80 billion a year.

The group includes software, chemical and steelmaking operations.

It owns Jaguar and Land Rover, and produces India's small car, the Nano. Tata also owns the Taj hotel chain.

Vice chancellor Fred Hilmer described Tata as 'a brilliant businessman both in India and internationally' and a 'driving force behind the resurgence of India as an economic and world power'.


Image: Ratan Tata.
Photographs: Reuters

? Copyright 2012 PTI. All rights reserved. Republication or redistribution of PTI content, including by framing or similar means, is expressly prohibited without the prior written consent.

Source: http://www.rediff.com/business/slide-show/slide-show-1-ratan-tata-positive-says-indias-outlook-not-as-bad/20121128.htm

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ScienceDaily: Gene News

ScienceDaily: Gene Newshttp://www.sciencedaily.com/news/health_medicine/genes/ Genes and Genetics News. Read today's medical research in genetics including what can damage genes, what can protect them, and more.en-usTue, 27 Nov 2012 06:23:34 ESTTue, 27 Nov 2012 06:23:34 EST60ScienceDaily: Gene Newshttp://www.sciencedaily.com/images/logosmall.gifhttp://www.sciencedaily.com/news/health_medicine/genes/ For more science articles, visit ScienceDaily.Metabolic protein launches sugar feast that nurtures brain tumorshttp://www.sciencedaily.com/releases/2012/11/121126164003.htm PKM2 slips into nucleus to promote cancer; potential biomarker and drug approach discovered.Mon, 26 Nov 2012 16:40:40 ESThttp://www.sciencedaily.com/releases/2012/11/121126164003.htmPossible new treatment for Ewing sarcomahttp://www.sciencedaily.com/releases/2012/11/121126142855.htm Discovery of a new drug with high potential to treat Ewing sarcoma, an often deadly cancer of children and young adults, and the previously unknown mechanism behind it, come hand-in-hand in a new study.Mon, 26 Nov 2012 14:28:28 ESThttp://www.sciencedaily.com/releases/2012/11/121126142855.htmSurvival gene may be key to controlling HIV and hepatitishttp://www.sciencedaily.com/releases/2012/11/121126131349.htm A newly discovered gene that is essential for embryo survival could also hold the key to treating and potentially controlling chronic infections such as HIV, hepatitis and tuberculosis. The gene, called Arih2, is fundamental to the function of the immune system -- making critical decisions about whether to switch on the immune response to an infection.Mon, 26 Nov 2012 13:13:13 ESThttp://www.sciencedaily.com/releases/2012/11/121126131349.htmMicrobial 'missing link' discovered after man impales hand on tree branchhttp://www.sciencedaily.com/releases/2012/11/121126110737.htm Two years ago, a 71-year-old Indiana man impaled his hand on a branch after cutting down a dead tree. The wound caused an infection that led scientists to discover a new bacterium and solve a mystery about how bacteria came to live inside insects.Mon, 26 Nov 2012 11:07:07 ESThttp://www.sciencedaily.com/releases/2012/11/121126110737.htmTransposable elements reveal a stem cell specific class of long noncoding RNAshttp://www.sciencedaily.com/releases/2012/11/121125192838.htm Over a decade after sequencing the human genome, it has now become clear that the genome is not mostly ?junk? as previously thought. In fact, the ENCODE project consortium of dozens of labs and petabytes of data have determined that these ?noncoding? regions house everything from disease trait loci to important regulatory signals, all the way through to new types of RNA-based genes.Sun, 25 Nov 2012 19:28:28 ESThttp://www.sciencedaily.com/releases/2012/11/121125192838.htmNew molecular culprit linked to breast cancer progressionhttp://www.sciencedaily.com/releases/2012/11/121124090511.htm Researchers have uncovered a protein ?partner? commonly used by breast cancer cells to unlock genes needed for spreading the disease around the body. A report on the discovery details how some tumors get the tools they need to metastasize.Sat, 24 Nov 2012 09:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121124090511.htmNew insights into virus proteome: Unknown proteins of the herpesvirus discoveredhttp://www.sciencedaily.com/releases/2012/11/121123092132.htm The genome encodes the complete information needed by an organism, including that required for protein production. Viruses, which are up to a thousand times smaller than human cells, have considerably smaller genomes. Using a type of herpesvirus as a model system scientists have shown that the genome of this virus contains much more information than previously assumed. The researchers identified several hundred novel proteins, many of which were surprisingly small.Fri, 23 Nov 2012 09:21:21 ESThttp://www.sciencedaily.com/releases/2012/11/121123092132.htmScientists describe elusive replication machinery of flu viruseshttp://www.sciencedaily.com/releases/2012/11/121122152928.htm Scientists have made a major advance in understanding how flu viruses replicate within infected cells. The researchers used cutting-edge molecular biology and electron-microscopy techniques to ?see? one of influenza?s essential protein complexes in unprecedented detail. The images generated in the study show flu virus proteins in the act of self-replication, highlighting the virus?s vulnerabilities that are sure to be of interest to drug developers.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152928.htmProtein folding: Look back on scientific advances made as result of 50-year old puzzlehttp://www.sciencedaily.com/releases/2012/11/121122152910.htm Fifty years after scientists first posed a question about protein folding, the search for answers has led to the creation of a full-fledged field of research that led to major advances in supercomputers, new materials and drug discovery, and shaped our understanding of the basic processes of life, including so-called "protein-folding diseases" such as Alzheimer's, Parkinson's and type II diabetes.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152910.htmStep forward in regenerating and repairing damaged nerve cellshttp://www.sciencedaily.com/releases/2012/11/121121145638.htm Researchers recently uncovered a nerve cell's internal clock, used during embryonic development. This breakthrough could lead to the development of new tools to repair and regenerate nerve cells following injuries to the central nervous system.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145638.htmArchitecture of rod sensory cilium disrupted by mutationhttp://www.sciencedaily.com/releases/2012/11/121121145621.htm Using a new technique called cryo-electron tomography, scientists have created a three-dimensional map that gives a better understanding of how the architecture of the rod sensory cilium (part of one type of photoreceptor in the eye) is changed by genetic mutation and how that affects its ability to transport proteins as part of the light-sensing process.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145621.htmAging: Scientists further unravel telomere biologyhttp://www.sciencedaily.com/releases/2012/11/121121130933.htm Researchers have resolved the structure of that allows a telomere-related protein, Cdc13, to form dimers in yeast. Mutations in this region of Cdc13 put the kibosh on the ability of telomerase and other proteins to maintain telomeres.Wed, 21 Nov 2012 13:09:09 ESThttp://www.sciencedaily.com/releases/2012/11/121121130933.htmDrug resistance biomarker could improve cancer treatmenthttp://www.sciencedaily.com/releases/2012/11/121121130811.htm Cancer therapies often have short-lived benefits due to the emergence of genetic mutations that cause drug resistance. A key gene that determines resistance to a range of cancer drugs has been reported in a new study. The study reveals a biomarker that can predict responses to cancer drugs and offers a strategy to treat drug-resistant tumors based on their genetic signature.Wed, 21 Nov 2012 13:08:08 ESThttp://www.sciencedaily.com/releases/2012/11/121121130811.htmGenome packaging: Key to breast cancer developementhttp://www.sciencedaily.com/releases/2012/11/121121130703.htm Two recent studies delve into the role of chromatin modifying enzymes and transcription factors in tumour cells. In one, it was found that the PARP1 enzyme activated by kinase CDK2 is necessary to induce the genes responsible for the proliferation of breast cancer cells in response to progesterone. In another, extensive work has been undertaken to identify those genes activated by the administration of progesterone in breast cancer, the sequences that can be recognized and how these genes are induced.Wed, 21 Nov 2012 13:07:07 ESThttp://www.sciencedaily.com/releases/2012/11/121121130703.htmShort DNA strands in genome may be key to understanding human cognition and diseaseshttp://www.sciencedaily.com/releases/2012/11/121121130643.htm Previously discarded, human-specific ?junk? DNA represents untapped resource in the study of diseases like Alzheimer?s and autism.Wed, 21 Nov 2012 13:06:06 ESThttp://www.sciencedaily.com/releases/2012/11/121121130643.htmBiomarking time: Methylome modifications offer new measure of our 'biological' agehttp://www.sciencedaily.com/releases/2012/11/121121130633.htm In a new study, researchers describe markers and a model that quantify how aging occurs at the level of genes and molecules, providing not just a more precise way to determine how old someone is, but also perhaps anticipate or treat ailments and diseases that come with the passage of time.Wed, 21 Nov 2012 13:06:06 ESThttp://www.sciencedaily.com/releases/2012/11/121121130633.htmKidney tumors have a mind of their ownhttp://www.sciencedaily.com/releases/2012/11/121121104552.htm New research has found there are several different ways that kidney tumors can achieve the same result -- namely, grow.Wed, 21 Nov 2012 10:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121121104552.htmMechanism to repair clumped proteins explainedhttp://www.sciencedaily.com/releases/2012/11/121121104416.htm Clumped proteins can be dissolved with the aid of cellular repair systems -- a process of critical importance for cell survival especially under conditions of stress. Researchers have now decrypted the fundamental mechanism for dissolving protein aggregates that involves specific molecular chaperones.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104416.htmNovel mechanism through which normal stromal cells become cancer-promoting stromal cells identifiedhttp://www.sciencedaily.com/releases/2012/11/121121104401.htm New understanding of molecular changes that convert harmless cells surrounding ovarian cancer cells into cells that promote tumor growth and metastasis provides potential new therapeutic targets for this deadly disease, according to new research.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104401.htmNew test for tuberculosis could improve treatment, prevent deaths in Southern Africahttp://www.sciencedaily.com/releases/2012/11/121120194932.htm A new rapid test for tuberculosis (TB) could substantially and cost-effectively reduce TB deaths and improve treatment in southern Africa -- a region where both HIV and tuberculosis are common.Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194932.htmEvolution of human intellect: Human-specific regulation of neuronal geneshttp://www.sciencedaily.com/releases/2012/11/121120194926.htm A new study has identified hundreds of small regions of the genome that appear to be uniquely regulated in human neurons. These regulatory differences distinguish us from other primates, including monkeys and apes, and as neurons are at the core of our unique cognitive abilities, these features may ultimately hold the key to our intellectual prowess (and also to our potential vulnerability to a wide range of 'human-specific' diseases from autism to Alzheimer's).Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194926.htmRibosome regulates viral protein synthesis, revealing potential therapeutic targethttp://www.sciencedaily.com/releases/2012/11/121120132906.htm Rather than target RNA viruses directly, aiming at the host cells they invade could hold promise, but any such strategy would have to be harmless to the host. Now, a surprising discovery made in ribosomes may point the way to fighting fatal viral infections such as rabies.Tue, 20 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121120132906.htmHow does antibiotic resistance spread? Scientists find answers in the nosehttp://www.sciencedaily.com/releases/2012/11/121120121835.htm Microbiologists studying bacterial colonization in mice have discovered how the very rapid and efficient spread of antibiotic resistance works in the respiratory pathogen, Streptococcus pneumoniae (also known as the pneumococcus). The team found that resistance stems from the transfer of DNA between bacterial strains in biofilms in the nasopharynx, the area just behind the nose.Tue, 20 Nov 2012 12:18:18 ESThttp://www.sciencedaily.com/releases/2012/11/121120121835.htmScientists identify inhibitor of myelin formation in central nervous systemhttp://www.sciencedaily.com/releases/2012/11/121120100155.htm Scientists have discovered another molecule that plays an important role in regulating myelin formation in the central nervous system. Myelin promotes the conduction of nerve cell impulses by forming a sheath around their projections, the so-called axons, at specific locations -- acting like the plastic insulation around a power cord.Tue, 20 Nov 2012 10:01:01 ESThttp://www.sciencedaily.com/releases/2012/11/121120100155.htm'Obese but happy gene' challenges the common perception of link between depression and obesityhttp://www.sciencedaily.com/releases/2012/11/121120084725.htm Researchers have discovered new genetic evidence about why some people are happier than others. The scientists have uncovered evidence that the gene FTO -- the major genetic contributor to obesity -- is associated with an eight per cent reduction in the risk of depression. In other words, it's not just an obesity gene but a "happy gene" as well.Tue, 20 Nov 2012 08:47:47 ESThttp://www.sciencedaily.com/releases/2012/11/121120084725.htmTelomere lengths predict life expectancy in the wild, research showshttp://www.sciencedaily.com/releases/2012/11/121119213144.htm Researchers have found that biological age and life expectancy can be predicted by measuring an individual's DNA. They studied the length of chromosome caps -- known as telomeres -- in a 320-strong wild population of Seychelles Warblers on a small isolated island.Mon, 19 Nov 2012 21:31:31 ESThttp://www.sciencedaily.com/releases/2012/11/121119213144.htmCancer: Some cells don't know when to stophttp://www.sciencedaily.com/releases/2012/11/121119171403.htm Certain mutated cells keep trying to replicate their DNA -- with disastrous results -- even after medications rob them of the raw materials to do so, according to new research.Mon, 19 Nov 2012 17:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121119171403.htmMultiple sclerosis ?immune exchange? between brain and blood is uncoveredhttp://www.sciencedaily.com/releases/2012/11/121119163301.htm DNA sequences obtained from a handful of patients with multiple sclerosis have revealed the existence of an ?immune exchange? that allows the disease-causing cells to move in and out of the brain.Mon, 19 Nov 2012 16:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121119163301.htmFruit fly studies guide investigators to molecular mechanism frequently misregulated in human cancershttp://www.sciencedaily.com/releases/2012/11/121119132056.htm Changes in how DNA interacts with histones ?- the proteins that package DNA ?- regulate many fundamental cell activities from stem cells maturing into a specific body cell type or blood cells becoming leukemic. These interactions are governed by a biochemical tug of war between repressors and activators, which chemically modify histones signaling them to clamp down tighter on DNA or move aside and allow a gene to be expressed.Mon, 19 Nov 2012 13:20:20 ESThttp://www.sciencedaily.com/releases/2012/11/121119132056.htm3-D light switch for the brain: Device may help treat Parkinson's, epilepsy; aid understanding of consciousnesshttp://www.sciencedaily.com/releases/2012/11/121119114249.htm A new tool for neuroscientists delivers a thousand pinpricks of light to individual neurons in the brain. The new 3-D "light switch", created by biologists and engineers, could one day be used as a neural prosthesis that could treat conditions such as Parkinson's and epilepsy by using gene therapy to turn individual brain cells on and off with light.Mon, 19 Nov 2012 11:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121119114249.htmNew factor of genetic susceptibility to Alzheimer's diseasehttp://www.sciencedaily.com/releases/2012/11/121119104944.htm A large-scale international study has just discovered a gene for susceptibility to a rare disease providing evidence of the heterogeneous aetiology of Alzheimer's disease.Mon, 19 Nov 2012 10:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121119104944.htmBlood cancer gene BCL6 identified as a key factor for differentiation of nerve cells of cerebral cortexhttp://www.sciencedaily.com/releases/2012/11/121119093848.htm The cerebral cortex is the most complex structure in our brain and the seat of consciousness, emotion, motor control and language. In order to fulfill these functions, it is composed of a diverse array of nerve cells, called cortical neurons, which are affected by many neurological and neuropsychiatric diseases. Researchers have opened new perspectives on brain development and stem cell neurobiology by discovering a gene called BCL6 as a key factor in the generation of cortical neurons during embryonic brain development.Mon, 19 Nov 2012 09:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121119093848.htmMinority report: Insight into subtle genomic differences among our own cellshttp://www.sciencedaily.com/releases/2012/11/121118141530.htm Scientists have demonstrated that induced pluripotent stem cells -- the embryonic-stem-cell look-alikes whose discovery a few years ago won this year's Nobel Prize in medicine -- are not as genetically unstable as was thought.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141530.htmSkin cells reveal DNA's genetic mosaichttp://www.sciencedaily.com/releases/2012/11/121118141524.htm The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141524.htmLikely basis of birth defect causing premature skull closure in infants identifiedhttp://www.sciencedaily.com/releases/2012/11/121118141432.htm Geneticists, pediatricians, surgeons and epidemiologists have identified two areas of the human genome associated with the most common form of non-syndromic craniosynostosis premature closure of the bony plates of the skull.Sun, 18 Nov 2012 14:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121118141432.htmDNA packaging discovery reveals principles by which CRC mutations may cause cancerhttp://www.sciencedaily.com/releases/2012/11/121117184658.htm A new discovery concerning a fundamental understanding about how DNA works will produce a "180-degree change in focus" for researchers who study how gene packaging regulates gene activity, including genes that cause cancer and other diseases.Sat, 17 Nov 2012 18:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121117184658.htmHepatitis C treatment's side effects can now be studied in the labhttp://www.sciencedaily.com/releases/2012/11/121116161059.htm Adverse side effects of certain hepatitis C medications can now be replicated in the lab, thanks to a research team. The new method aids understanding of recent failures of hepatitis C antiviral drugs in some patients, and could help to identify medications that eliminate adverse effects. The findings may aid the development of safer and more effective treatments for hepatitis C and other pathogens such as SARS and West Nile virus.Fri, 16 Nov 2012 16:10:10 ESThttp://www.sciencedaily.com/releases/2012/11/121116161059.htmReconsidering cancer's bad guyhttp://www.sciencedaily.com/releases/2012/11/121116124644.htm Researchers have found that a protein, known for causing cancer cells to spread around the body, is also one of the molecules that trigger repair processes in the brain.Fri, 16 Nov 2012 12:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121116124644.htmGene distinguishes early birds from night owls and helps predict time of deathhttp://www.sciencedaily.com/releases/2012/11/121116124551.htm New research shows that a gene is responsible for a person's tendency to be an early riser or night owl -- and helps determine the time of day a person is most likely to die.Fri, 16 Nov 2012 12:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121116124551.htmClues to cause of kids' brain tumorshttp://www.sciencedaily.com/releases/2012/11/121116091226.htm Insights from a genetic condition that causes brain cancer are helping scientists better understand the most common type of brain tumor in children.Fri, 16 Nov 2012 09:12:12 ESThttp://www.sciencedaily.com/releases/2012/11/121116091226.htmArthritis study reveals why gender bias is all in the geneshttp://www.sciencedaily.com/releases/2012/11/121115210541.htm Researchers have pieced together new genetic clues to the arthritis puzzle in a study that brings potential treatments closer to reality and could also provide insights into why more women than men succumb to the disabling condition.Thu, 15 Nov 2012 21:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121115210541.htmClass of RNA molecules protects germ cells from damagehttp://www.sciencedaily.com/releases/2012/11/121115172255.htm Passing one's genes on to the next generation is a mark of evolutionary success. So it makes sense that the body would work to ensure that the genes the next generation inherits are exact replicas of the originals. Biologists have now identified one way the body does exactly that.Thu, 15 Nov 2012 17:22:22 ESThttp://www.sciencedaily.com/releases/2012/11/121115172255.htmQuick test speeds search for Alzheimer's drugs: Compound restores motor function and longevity to fruit flieshttp://www.sciencedaily.com/releases/2012/11/121115152655.htm Researchers report that an efficient, high-volume technique for testing potential drug treatments for Alzheimer's disease uncovered an organic compound that restored motor function and longevity to fruit flies with the disease.Thu, 15 Nov 2012 15:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115152655.htmProtein-making machinery can switch gears with a small structural change process; Implications for immunity and cancer therapyhttp://www.sciencedaily.com/releases/2012/11/121115133414.htm For the past several years, research has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in translation, the process of producing proteins. In a new study, scientists have shown that this enzyme can actually also work in another fundamental process in humans.Thu, 15 Nov 2012 13:34:34 ESThttp://www.sciencedaily.com/releases/2012/11/121115133414.htmPlant derivative, tanshinones, protects against sepsis, study suggestshttp://www.sciencedaily.com/releases/2012/11/121115133312.htm Researchers have discovered that tanshinones, which come from the plant Danshen and are highly valued in Chinese traditional medicine, protect against the life-threatening condition sepsis.Thu, 15 Nov 2012 13:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121115133312.htmStructure of enzyme topoisomerase II alpha unravelled providing basis for more accurate design of chemotherapeutic drugshttp://www.sciencedaily.com/releases/2012/11/121115132903.htm Medical researchers have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs. The type II topoisomerases are important enzymes that are involved in maintaining the structure of DNA and chromosome segregation during both replication and transcription of DNA. One of these enzymes, topoisomerase II alpha, is involved in the replication of DNA and cell proliferation, and is highly expressed in rapidly dividing cancer cells.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132903.htmNewly discovered enzyme important in the spreading of cancerhttp://www.sciencedaily.com/releases/2012/11/121115132901.htm Enzyme hunters at UiO have discovered the function of an enzyme that is important in the spreading of cancer. Cancer researchers now hope to inhibit the enzyme.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132901.htmGenetics point to serious pregnancy complication, pre-eclampsiahttp://www.sciencedaily.com/releases/2012/11/121115132613.htm New research has revealed a genetic link in pregnant moms - and their male partners - to pre-eclampsia, a life-threatening complication during pregnancy.Thu, 15 Nov 2012 13:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115132613.htmMolecular mechanisms underlying stem cell reprogramming decodedhttp://www.sciencedaily.com/releases/2012/11/121115132344.htm Thanks to some careful detective work, scientist better understand just how iPS cells form ? and why the Yamanaka process is inefficient, an important step to work out for regenerative medicine. The findings uncover cellular impediments to iPS cell development that, if overcome, could dramatically improve the efficiency and speed of iPS cell generation.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132344.htmSurprising genetic link between kidney defects and neurodevelopmental disorders in kidshttp://www.sciencedaily.com/releases/2012/11/121115132342.htm About 10 percent of kids born with kidney defects have large alterations in their genomes known to be linked with neurodevelopmental delay and mental illness, a new study has shown.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132342.htmEven moderate drinking in pregnancy can affect a child's IQhttp://www.sciencedaily.com/releases/2012/11/121114172833.htm Relatively small levels of exposure to alcohol while in the womb can influence a child's IQ, according to a new study using data from over 4,000 mothers and their children.Wed, 14 Nov 2012 17:28:28 ESThttp://www.sciencedaily.com/releases/2012/11/121114172833.htmGene nearly triples risk of Alzheimer's, international research team findshttp://www.sciencedaily.com/releases/2012/11/121114171710.htm A gene so powerful it nearly triples the risk of Alzheimer's disease has been discovered by an international team of researchers. It is the most potent genetic risk factor for Alzheimer's identified in the past 20 years.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171710.htmDiscovery could lead to faster diagnosis for some chronic fatigue syndrome caseshttp://www.sciencedaily.com/releases/2012/11/121114171708.htm For the first time, researchers have landed on a potential diagnostic method to identify at least a subset of patients with chronic fatigue syndrome - testing for antibodies linked to latent Epstein-Barr virus reactivation.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171708.htmResearch breakthrough could halt melanoma metastasis, study suggestshttp://www.sciencedaily.com/releases/2012/11/121114153227.htm In laboratory experiments, scientists have eliminated metastasis, the spread of cancer from the original tumor to other parts of the body, in melanoma by inhibiting a protein known as melanoma differentiation associated gene-9 (mda-9)/syntenin.Wed, 14 Nov 2012 15:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114153227.htmPig genomes provide massive amount of genomic data for human healthhttp://www.sciencedaily.com/releases/2012/11/121114134512.htm Researchers provide a whole-genome sequence and analysis of number of pig breeds, including a miniature pig that serves a model for human medical studies and therapeutic drug testing.Wed, 14 Nov 2012 13:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121114134512.htmRare parasitic fungi could have anti-flammatory benefitshttp://www.sciencedaily.com/releases/2012/11/121114134054.htm Caterpillar fungi are rare parasites found on hibernating caterpillars in the mountains of Tibet. For centuries they have been highly prized as a traditional Chinese medicine - just a small amount can fetch hundreds of dollars.Wed, 14 Nov 2012 13:40:40 ESThttp://www.sciencedaily.com/releases/2012/11/121114134054.htmCancer therapy: Nanokey opens tumors to attackhttp://www.sciencedaily.com/releases/2012/11/121114113803.htm There are plenty of effective anticancer agents around. The problem is that, very often, they cannot gain access to all the cells in solid tumors. A new gene delivery vehicle may provide a way of making tracks to the heart of the target.Wed, 14 Nov 2012 11:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121114113803.htmHigh sperm DNA damage a leading cause of 'unexplained infertility', research findshttp://www.sciencedaily.com/releases/2012/11/121114113235.htm New research has uncovered the cause of infertility for 80 per cent of couples previously diagnosed with 'unexplained infertility': high sperm DNA damage.Wed, 14 Nov 2012 11:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114113235.htmA risk gene for cannabis psychosishttp://www.sciencedaily.com/releases/2012/11/121114083928.htm The ability of cannabis to produce psychosis has long been an important public health concern. This concern is growing in importance as there is emerging data that cannabis exposure during adolescence may increase the risk of developing schizophrenia, a serious psychotic disorder. Further, with the advent of medical marijuana, a new group of people with uncertain psychosis risk may be exposed to cannabis.Wed, 14 Nov 2012 08:39:39 ESThttp://www.sciencedaily.com/releases/2012/11/121114083928.htmBacterial DNA sequence used to map an infection outbreakhttp://www.sciencedaily.com/releases/2012/11/121113214635.htm For the first time, researchers have used DNA sequencing to help bring an infectious disease outbreak in a hospital to a close. Researchers used advanced DNA sequencing technologies to confirm the presence of an ongoing outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in a Special Care Baby Unit in real time. This assisted in stopping the outbreak earlier, saving possible harm to patients. This approach is much more accurate than current methods used to detect hospital outbreaks.Tue, 13 Nov 2012 21:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121113214635.htm

Source: http://www.sciencedaily.com/rss/health_medicine/genes.xml

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Tuesday, November 27, 2012

Black Friday record: Weekend sales up 13 percent

Black Friday record pushes spending to $59 billion over four days. By extending Black Friday, retailers made it easy to shop and drew in record numbers of shoppers.?

By Anne D'Innocenzio,?AP Retail Writer / November 26, 2012

In this Friday file photo, Black Friday shoppers pour into the Valley River Center mall for the Midnight Madness sale, in Eugene, Ore. Some 247 million shoppers hit stores over the four-day weekend, setting a Black Friday record, according to a survey released by the National Retail Federation on Sunday.

Brian Davies/The Register-Guard/AP/File

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If you make holiday shopping convenient, Americans will come in droves.

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It's estimated that U.S. shoppers hit stores and websites at record numbers over the Thanksgiving weekend, according to a survey released by the National Retail Federation on Sunday, setting a Black Friday record. They were attracted by retailers' efforts to make shopping easier, including opening stores on Thanksgiving evening, updating mobile shopping applications for smartphones and tablets, and expanding shipping and layaway options.

All told, a record 247 million shoppers visited stores and websites over the four-day weekend starting on Thanksgiving, up 9.2 percent of last year, according to a survey of 4,000 shoppers that was conducted by research firm BIGinsight for the trade group. Americans spent more too: The average holiday shopper spent $423 over the entire weekend, up from $398 last year. Total spending over the four-day weekend totaled $59.1 billion, up 12.8 percent from 2011.

Caitlyn Maguire, 21, was one of the shoppers that took advantage of all the new conveniences of shopping this year. Maguire, who lives in New York, began buying on Thanksgiving night at Target's East Harlem store. During the two-hour wait in line, she also bought items on her iPhone on Amazon.com. On?Friday, she picked up a few toys at Toys R Us. And on Saturday she was out at the stores again.

"I'm basically done," said Maguire, who spent about $400 over the weekend.

The results for the weekend appear to show that retailers' efforts to make shopping effortless for U.S. consumers during the holiday shopping season worked. Retailers upped the ante in order to give Americans more reasons to shop. Stores feared that consumers might not spend because of the weak job market and worries that tax increases and budget cuts will take effect if Congress fails to reach a budget deal by January.

Retailers, which can make up to 40 percent of their annual revenue in November and December, were hoping Thanksgiving openings and other incentives would help boost what's expected to be a difficult holiday shopping season. The National Retail Federation estimates that overall sales in November and December will rise 4.1 percent this year to $586.1 billion. That's more than a percentage point lower than the growth in each of the past two years, and the smallest increase since 2009, when sales were nearly flat.

Matthew Shay, president and CEO of the National Retail Federation, said retailers can be encouraged by the first weekend of the holiday shopping season.

"Retailers and consumers both won this weekend, especially on Thanksgiving," he said.

Here were the trends that emerged over the weekend:

? Online wave: According to comScore, which tracks online spending, online sales rose 26 percent to $1.04 billion on?Black?Friday?compared with a year ago. On Thanksgiving, online sales rose 32 percent from last year to $633 million. And online sales onBlack?Friday?were up 26 percent from the same day last year to $1.042 billion. It was the first time online sales on?Black?Friday?surpassed $1 billion.

? Thanksgiving shopping: Many stores, including Toys R Us and Target, opened on Thanksgiving evening this year. No data is out yet about how much shoppers spent on that day, but it appears that consumers took advantage of the earlier start: According to the National Retail Federation's survey, the number of people who shopped on Thanksgiving rose 23.1 percent. That compares with a 3.1 percent increase forBlack?Friday.

Linda and James Michaels of Portland, Ore., were among those shopping on Thanksgiving. They hit up the big sales on the day and got everything they were hoping for that night.

They picked up remote control cars and some Mickey Mouse items on sale at Toys R Us. Then they went a few doors down to Target and scored the last Operation game on sale for $7. They were even able to pick up some pajamas and shoes along the way for the kids. In total they spent about $300.

"I felt lucky that I caught the deals and there was no craziness, no fighting," said Linda Michaels. "I was nervous."

ShopperTrak, which analyzes customer traffic at 40,000 U.S. stores, plans to release sales data for Thanksgiving later this week, but the firm is estimating that retailers generated $700 million in sales on the holiday.

??Black?Friday?flop: It appears that the Thanksgiving openings may have hurt sales on the day after.

Black?Friday?is still expected to be the biggest shopping day of the year, but sales on that day slipped to $11.2 billion, down 1.8 percent from last year, according to ShopperTrak. That's below ShopperTrak's estimate that?Black?Friday?sales would rise 3.8 percent to $11.4 billion.

Karen MacDonald, a spokeswoman at Taubman Centers, which operates 28 malls across the country, said that Thanksgiving openings hurt business. Based on a sampling of 10 malls, sales growth was unchanged up to mid-single digits on?Friday, and unchanged up to low single digit on Saturday.

"It was a different feeling," she said. "It was a good?Black?Friday, but I don't think it was great."

The disappointing sales on?Black?Friday?may have been the result of shoppers like Miguel Garcia, a 40-year-old office coordinator.

"I can't deal with all that craziness," said Garcia, who was at a Target in the Bronx borough of New York City on Saturday. "Compared to what I saw on TV yesterday, this is so much more comfortable and relaxed. I can actually think straight and compare prices."

AP writers Rodrigue Ngowi in Watertown, Mass., Juan Carolos Llorca in El Paso, Texas, and Candice Choi in New York contributed to this report

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/zFkfkanzwEs/Black-Friday-record-Weekend-sales-up-13-percent

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UIC scientists find ancient microbes in salty, ice-sealed Antarctic lake

UIC scientists find ancient microbes in salty, ice-sealed Antarctic lake [ Back to EurekAlert! ] Public release date: 26-Nov-2012
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Contact: Anne Brooks Ranallo
annebr@sbcglobal.net
312-355-2523
University of Illinois at Chicago

Shedding light on the limits of life in extreme environments, scientists have discovered abundant and diverse metabolically active bacteria in the brine of an Antarctic lake sealed under more than 65 feet of ice.

The finding, described in this week's issue of the Proceedings of the National Academy of Sciences, is surprising because previous studies indicate that the brine has been isolated from the surface environment -- and external sources of energy -- for at least 2,800 years, according to two of the report's authors, Peter Doran and Fabien Kenig, both professors of earth and environmental sciences at the University of Illinois at Chicago.

"This provides us with new boundary conditions on the limits for life," said Doran. "The low temperature or high salinity on their own are limiting, but combined with an absence of solar energy or any new inputs from the atmosphere, they make this a very tough place to make a living."

The researchers drilled out cores of ice, using sanitary procedures and equipment. They collected samples of brine within the ice and assessed its chemical qualities and potential for sustaining life.

They found that the brine is oxygen-free, slightly acidic, and contains high levels of organic carbon, molecular hydrogen, and both oxidized and reduced compounds. The findings were unexpected because of the extremely salty, dark, cold, isolated ecosystem within the ice.

"Geochemical analyses suggest that chemical reactions between the brine and the underlying sediment generate nitrous oxide and molecular hydrogen," said Kenig. "The hydrogen may provide some of the energy needed to support microbes."

"We'd like to go back and find if there is a proper body of brine without ice down there," said Doran. "We'd also like to get some sediment cores from below that to better establish the history of the lake. In the meantime, we are using radar and other geophysical techniques to probe what lies beneath."

The research was conducted with Alison Murray and colleagues at the Desert Research Institute and scientists at other institutes.

###

Funding was provided by the National Science Foundation and NASA.

UIC ranks among the nation's leading research universities and is Chicago's largest university with 27,500 students, 12,000 faculty and staff, 15 colleges and the state's major public medical center. A hallmark of the campus is the Great Cities Commitment, through which UIC faculty, students and staff engage with community, corporate, foundation and government partners in hundreds of programs to improve the quality of life in metropolitan areas around the world.

NOTE: Please refer to the institution as the University of Illinois at Chicago on first reference and UIC on second reference. "University of Illinois" and "U. of I." are often assumed to refer to our sister campus in Urbana-Champaign.


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UIC scientists find ancient microbes in salty, ice-sealed Antarctic lake [ Back to EurekAlert! ] Public release date: 26-Nov-2012
[ | E-mail | Share Share ]

Contact: Anne Brooks Ranallo
annebr@sbcglobal.net
312-355-2523
University of Illinois at Chicago

Shedding light on the limits of life in extreme environments, scientists have discovered abundant and diverse metabolically active bacteria in the brine of an Antarctic lake sealed under more than 65 feet of ice.

The finding, described in this week's issue of the Proceedings of the National Academy of Sciences, is surprising because previous studies indicate that the brine has been isolated from the surface environment -- and external sources of energy -- for at least 2,800 years, according to two of the report's authors, Peter Doran and Fabien Kenig, both professors of earth and environmental sciences at the University of Illinois at Chicago.

"This provides us with new boundary conditions on the limits for life," said Doran. "The low temperature or high salinity on their own are limiting, but combined with an absence of solar energy or any new inputs from the atmosphere, they make this a very tough place to make a living."

The researchers drilled out cores of ice, using sanitary procedures and equipment. They collected samples of brine within the ice and assessed its chemical qualities and potential for sustaining life.

They found that the brine is oxygen-free, slightly acidic, and contains high levels of organic carbon, molecular hydrogen, and both oxidized and reduced compounds. The findings were unexpected because of the extremely salty, dark, cold, isolated ecosystem within the ice.

"Geochemical analyses suggest that chemical reactions between the brine and the underlying sediment generate nitrous oxide and molecular hydrogen," said Kenig. "The hydrogen may provide some of the energy needed to support microbes."

"We'd like to go back and find if there is a proper body of brine without ice down there," said Doran. "We'd also like to get some sediment cores from below that to better establish the history of the lake. In the meantime, we are using radar and other geophysical techniques to probe what lies beneath."

The research was conducted with Alison Murray and colleagues at the Desert Research Institute and scientists at other institutes.

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Funding was provided by the National Science Foundation and NASA.

UIC ranks among the nation's leading research universities and is Chicago's largest university with 27,500 students, 12,000 faculty and staff, 15 colleges and the state's major public medical center. A hallmark of the campus is the Great Cities Commitment, through which UIC faculty, students and staff engage with community, corporate, foundation and government partners in hundreds of programs to improve the quality of life in metropolitan areas around the world.

NOTE: Please refer to the institution as the University of Illinois at Chicago on first reference and UIC on second reference. "University of Illinois" and "U. of I." are often assumed to refer to our sister campus in Urbana-Champaign.


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Source: http://www.eurekalert.org/pub_releases/2012-11/uoia-usf112612.php

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Is DIY In Your DNA? | Fast Horse

I grew up in a very DIY family. My parents built our first home, and I mean they actually built it. There was no hiring out of tough jobs or allowing others to oversee the process; they built a two-story, three-bedroom home from the ground up. My mother hung sheet rock and laid tile all while nine months pregnant with me. She?s a brute.

When I was 10, we moved to town and lived in a home that was built in 1877. My parents gutted the entire thing and, you guessed it, started from scratch so they could DIY. By this time I was accustomed to falling asleep to my father pounding nails or sanding floors, but after a while I just wanted a ?normal? house without an inch of?sheet rock?dust under my feet. I always swore to my parents that I would NEVER live in an unfinished home when I grew up, and would always hire other people to do the work.

My actual floor.

Ha! Fast forward to today and guess what I did all weekend ? sanded our hardwood floors so we could re-stain them. Yep, the DIY bug was not something I could escape from and now I live in a ?fixer upper? and can honestly say that I am proud to be a DIYer.

I have to give props to my ?rents for doing all this DIYing before there was an arsenal of tips and tricks available at their fingertips. When my boyfriend and I encounter a problem, we have the option of quickly looking up a how-to on YouTube or a quick search in Google to help us solve the issue. My favorite way of acquiring information is a good ol? DIY/home improvement blog. I love a good blog. A step-by-step guide to how the average Joe attacks a home improvement project, along with real-life tid bits of information that you only get from messing it up yourself first.

I am such a fan of a certain DIY blog that I recently stood in line for four hours to catch a glimpse of the real people behind my favorite blog, Young House Love. I?ve followed this blog religiously well before I had my own home to renovate, but fell in love with their quirky style and funny home improvement tips enough to check their blog daily (sometimes multiple times a day).

So whether you fancy yourself a?die-hard?home improvement buff like my parents or maybe you reach your limit at painting an accent wall, in today?s DIY-world you will always have a place to find inspiration and guidance. Maybe you will even become so inspired (see Young House Love, I swear you will get hooked) that you will completely change your mind, like me, and decide doing it yourself?isn?t?so bad after all.

Source: http://fasthorseinc.com/blog/2012/11/27/is-diy-in-your-dna/

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