NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study

??NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study

Background Cell surface NKG2D ligands (NKG2DL) bind to the activating NKG2D receptor present on NK cells and subsets of T cells, thus playing a role in initiating an immune response. We examined tumor expression and prognostic effect of NKG2DL in breast cancer patients.Methods Our study population (n=677) consisted of all breast cancer patients primarily treated with surgery in our center between 1985 and 1994.

Formalin-fixed paraffin-embedded tumor tissue was immunohistochemically stained with antibodies directed against MIC-A/MIC-B (MIC-AB), ULBP-1, ULBP-2, ULBP-3, ULBP-4, and ULBP-5.Results NKG2DL were frequently expressed by tumors (MIC-AB, 50% of the cases; ULBP-1, 90%; ULBP-2, 99%; ULBP-3, 100%; ULBP-4, 26%; ULBP-5, 90%) and often showed co-expression: MIC-AB and ULBP-4 (p=0.043), ULBP-1 and ULBP-5 (p=0.006), ULBP-4 and ULBP-5 (p

Combined expression of these ligands showed to be an independent prognostic parameter for RFP (p

Expression of MIC-AB and ULBP-2 resulted in a statistically significant beneficial outcome concerning RFP with high discriminative power. Combination of all NKG2DL showed no additive or interactive effect of ligands on each other, suggesting that similar and co-operative functioning of all NKG2DL can not be assumed.

Our observations suggest that among driving forces in breast cancer outcome are immune activation on one site and tumor immune escape on the other site.

Author: Esther M de KruijfAnita SajetJohanna GH van NesHein PutterVincent THBM SmitRobert A EagleInsiya JafferjiJohn TrowsdaleGerrit Jan LiefersCornelis JH van de VeldePeter JK Kuppen
Credits/Source: BMC Cancer 2012, 12:24

Published on: 2012-01-18

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